Nowadays implanting of artificial blood vessels is a widespread method of heart disease therapy. However sometimes it leads to partial or complete blockage of a vessel. To eliminate this consequence patients have to take blood thinners.
The group of researchers under the leadership of Vladimir Vinogradov, the head of the International Laboratory “Solution Chemistry of Advanced Materials and Technologies”, developed the thrombolytic sol–gel coating for vascular grafts. Thanks to its nanoarchitecture the problem area of the blood system is always supplied with the necessary thrombolytic enzymes that prevent clots from appearing.
“This coating provides unhampered bloodstream preventing thrombosis,” said Yulia Chapurina, Master Student and one of the inventors of the project.
Modern vascular grafts are medicated and they emit the drug into the bloodstream. However the concentration of the medication in the graft decreases with time and then clots may reappear. The new technology is based on drug entrapping. It means that the protective coating holds it inside the vascular graft, which makes the productive lifespan of such graft virtually limitless.
The researchers of ITMO University published results of their research in the “Journal of Medicinal Chemistry”.
Aleksander Pushkash
News portal editorial office