Search by tag «Itaconate» 1 results

• Scientists “Hack” Regulatory Mechanism of Immune Cell Activity

  An international research team has described new molecular mechanisms regulating the activity of macrophages, which are crucial elements of the immune response, in a breakthrough project. Macrophage activation is regulated by the level of itaconate, which has various effects on the production of substances causing inflammation. Regulatory pathways of itaconate and its derivatives are associated with the pathogenesis of some autoimmune diseases. Experiments on mice and isolated human cells have shown that these substances can significantly alleviate the symptoms of psoriasis. The results of this study are published in Nature.

  19.04.2018