Search by tag «Genes» 10 results
Scientists from ITMO’s International Laboratory “Computer Technologies” have launched GATOM, a new version of their online service GAM (Genes and Metabolites). The platform analyzes the gene expression and cell processes, as well as looks for the connections between them. This helps researchers figure out how, for instance, the cells of an immune system function. The scientists are confident that their tool will not only help better understand biological processes at the cellular level but also benefit the development of treatment for autoimmune diseases and cancer.
For several years Bayazit Yunusbayev had been studying the mechanisms behind the autoimmune and allergic diseases at the University of Tartu (Estonia), and last year he joined ITMO’s SCAMT Institute, where he heads the Evolutionary Biomedicine group, to continue with his research. Bayazit Yunusbayev came to the university as part of the ITMO Fellowship & Professorship program that allows researchers to work at the university for several years. Read on to learn more about gene mutations responsible for immune system adaptation and discover other areas studied by the lab.
Researchers from ITMO’s Laboratory of Genomic Diversity and the World-Class Research Centre for Personalized Medicine have developed GPrior (gene prioritizer), an algorithm that uses data from a genome-wide association study (GWAS) to identify the genes responsible for a particular disease. For this study, the group used the data on schizophrenia, coronary heart disease, and inflammatory bowel diseases to test the algorithm. Read on to learn more about GPrior’s development and prospects.
The method can be used to assess the probability of a specific gene or genes affecting various processes in an organism, including the development of diseases. The article was published in BMC Bioinformatics.
Will humanity ever stop aging and dying? Does fasting really prolong one’s life? And what does the naked sand rat have to do with it? Dmitriy Madera, head of the molecular genetics department of the innovative company BIOCAD, gave a detailed lecture on the issues of aging at the Okhta-8 creative space.
An international research team that includes specialists from ITMO University has conducted a series of experiments with the goal of studying the immune system and identifying the genes and proteins involved in the response to certain harmful bacteria. The scientists found that “turning off” a gene responsible for the production of the protein Beclin 1, or the gene that produces the FIP200 protein, resulted in the test animals becoming nearly completely immune to the infectious disease listeriosis. The results of this research have been published in Nature Microbiology.
An international team of researchers from ITMO University and the University of Washington in St. Louis has developed a new method for determining cell types in tissue samples. The scientists identified typical signs of genes activity in different cell types and, using this as a basis, made a model capable of recognizing different cell types in mixed samples. As this approach works for all tissues, it can be used to, for example, establish how the ratio of different cell types is associated with the survival of patients with different types of cancer. The results are published in Nature Communications.
It has been 15 years since the conclusion of the Human Genome Project, one of the 20th century’s major research projects. One of its consequences was the public availability of genomics methods. Today, anyone can take a genetic test to learn about their ancestry. We spoke to bioinformatics experts from ITMO University’s Computer Technologies Laboratory to learn how genetic testing works, its scientific significance, which methods are trustworthy, and which ones aren’t.
An international research team has developed a new animal model used to study the pathogenesis of the Zika virus. Scientists were able to make the disease develop in mice in a way that is similar to what happens in humans. The new model reflects the most dangerous manifestation of the Zika virus: infection of the fetus from a pregnant woman, which leads to developmental problems. Such an advancement was achieved due to a new, more pathogenic virus strain, as well as a specially bred group of mice with a human-like immune response. The new model paves the way for more detailed study of the Zika virus, which should result in a more effective fight against it. The research is published in Cell Host & Microbe.
Researchers from ITMO University and the Center of Physical and Chemical Medicine have developed an algorithm capable of tracking the spread of antibiotic resistance genes in gut microbiota DNA and revealed additional evidence of resistance gene transfer between different bacterial species. The method can not only contribute to the development of effective therapy schemes, but also curb the spread of superbugs. The results of the research were published in Bioinformatics journal.