Search by tag «Drug Delivery» 11 results
In today’s science digest, it’s all about interdisciplinarity: whether it’s physics combined with biology, biology with medicine, or medicine with chemistry, we’ll be shining a light on the remarkable things that happen when scientists of all fields work together for a common good. Let’s have a look!
The researchers from ITMO’s Faculty of Physics have created a multifunctional system for drug delivery capable of monitoring temperature inside living cells in real-time. Read on to learn what scientists need these measurements for and how they can be taken at the nanoscale.
The coating is based on active substances, in particular, bone morphogenetic protein 2 (BMP-2), loaded into the titania layer and modified by polypyrrole. If this coating is fabricated on the implant surface, it is possible to accelerate the injury recovery and to control this process using infrared radiation (IR).
Researchers have created drug delivery systems based on hollow calcium carbonate particles, resembling the E. coli K12 bacterium in shape. This approach may potentially allow further development of carriers that can be perceived by pathogens as their own cells, integrate into bacterial biofilms, and release a therapeutic agent in a controlled manner, when necessary.
The concept is based on the interaction of resonant semiconductor iron oxide Fe2O3 nanoparticles with light. They can get heated locally by a laser and convert the absorbed light into heat. If you modify the shell of the polymer containers (capsules) that are widely used as a carriers for the delivery of bioactive compounds in cells and irradiate them with a laser, the heat will deform the capsules and the loaded compounds will be released at the desired location and time. The research was published in Laser and Photonics Reviews.
ITMO University’s international research center SCAMT, together with specialists from the Mariinskaya Hospital, continues to work on a new thrombolytic drug. Based on the results of preliminary tests, magnetically controlled particles can break down blood clots significantly more effectively than the drugs currently used. In 2018, the treatment underwent preclinical tests. ITMO.NEWS met SCAMT head Vladimir Vinogradov and Ivan Dudanov, head of the Regional Vascular Center, operating surgeon at the Mariinskaya Hospital and professor, to learn about the tests that await the new drug, what’s needed to be done to introduce it to the market and when this could happen.
Targeted Drug Delivery, Multidimensional Blockchain, and Vision Enhancement: ITMO University’s Young Scientists Win SIE Support Grants
Eight Master’s and PhD students have been named among this year’s winners of the grant program UMNIK (Russian: “brainiac”), organized by the Foundation for Assistance to Small Innovative Enterprises (FASIE). We’ve spoken to some of the young scientists to learn what they plan to do with their grants.
Gary Hix is a professor of the University of Wolverhampton (the UK) and the head of Wolverhampton School of Sciences. Together with his research team, Prof. Hix designs anti-bacterial medical materials. In an open lecture at ITMO University, he spoke about organic-inorganic hybrid materials, metal phosphonates and oxides, and how these substances are produced. Speaking about anti-bacterial materials, Prof. Hix explained the effect of their structure on the discharge of active substances and how these materials are made to possess therapeutic qualities.
Researchers from ITMO University developed special nanocontainers that can translate the light signal into metabolic changes in bacteria. The containers consist of titanium dioxide nanoparticles coated with silver and polymers. Once the particles are heated with laser irradiation, the polymer conformation changes and the container opens, releasing the contents. Scientists tested the new system’s performance using a model enzyme, arabinose. However, it can be replaced with other active substances in order to use the containers for drug delivery. The research was published in Bioconjugate Chemistry.
New anti-thrombosis drug based on magnetite nanoparticles and developed at ITMO University has been successfully tested on animals. Preclinical studies conducted as part of the project "PHARMA 2020" showed the drug’s high efficacy and no side effects, with the clot dissolution rate being twenty times shorter than that of traditional medications. The range of permissible concentrations is very high, and the minimum dose of the active substance required to achieve the desired effect was a hundred times smaller than usual. The results are published in Applied Materials and Interfaces.